Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders
Abstract Calsequestrin is among the most abundant proteins in muscle sarcoplasmic Show Your Pride reticulum and displays a high capacity but a low affinity for Ca2+ binding.In mammals, calsequestrin is encoded by two genes, CASQ1 and CASQ2, which are expressed almost exclusively in skeletal and cardiac muscles, respectively.Phylogenetic analysis in